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Tumor immunotherapy and intestinal flora

Tumor immunotherapy is an emerging method of tumor therapy, which mainly controls and kills tumor cells by stimulating the body's immune system and enhancing its own anti-tumor immunity. Tumor immunotherapy is one of the most active and promising therapies in the comprehensive treatment model of cancer, and was rated as one of the "top 10 scientific breakthroughs" in 2013 by the journal Science. The gut is the largest lymphoid organ in the human body, with more than 70% of the T cells, and is home to the vast majority of memory T cells. Intestinal flora can interact with host immune system through various mechanisms such as direct physical contact metabolites and changes in intestinal mucosal structure components. At the beginning of 2018, the international top journal "Science" published three blockbuster articles, focusing on the important influence of intestinal microbes on tumor immunotherapy, and proving that intestinal flora in human can affect the efficacy of tumor immunotherapy.

The experimental method

Total exon sequencing, 16S amplicon sequencing, metagenomic sequencing, metabolome detection, sterile animal model.

Technical route
Presentation of analysis results

 

肿瘤免疫治疗与肠道菌群研究方案设计 免疫治疗响应组与未响应组肠道菌群差异

                                                                                                                     

免疫治疗响应组与未响应组肠道菌群基因功能差异 无菌动物功能验证

                                                                                                                      

 




Application field

Tumor immunotherapy and intestinal flora using multiple omics research techniques, including exon group, metagenomic transcription, macro, macro metabolic group, etc., to explore the curative effect and prognosis of tumor immunotherapy, the side effects associated with the intestinal flora, intestinal flora influence mechanism of the effect of tumor immunotherapy, eventually selected curative effect and prognosis prediction of intestinal flora markers, and developing new probiotics to improve the effect of tumor immunotherapy, help clinical cancer treatment. The study of tumor immunotherapy and intestinal flora can be applied to the study of intestinal flora with different cancer species and different immunotherapy strategies.

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