Tumor immunotherapy is an emerging method of tumor therapy, which mainly controls and kills tumor cells by stimulating the body's immune system and enhancing its own anti-tumor immunity. Tumor immunotherapy is one of the most active and promising therapies in the comprehensive treatment model of cancer, and was rated as one of the "top 10 scientific breakthroughs" in 2013 by the journal Science. The gut is the largest lymphoid organ in the human body, with more than 70% of the T cells, and is home to the vast majority of memory T cells. Intestinal flora can interact with host immune system through various mechanisms such as direct physical contact metabolites and changes in intestinal mucosal structure components. At the beginning of 2018, the international top journal "Science" published three blockbuster articles, focusing on the important influence of intestinal microbes on tumor immunotherapy, and proving that intestinal flora in human can affect the efficacy of tumor immunotherapy.
Total exon sequencing, 16S amplicon sequencing, metagenomic sequencing, metabolome detection, sterile animal model.
Tumor immunotherapy and intestinal flora using multiple omics research techniques, including exon group, metagenomic transcription, macro, macro metabolic group, etc., to explore the curative effect and prognosis of tumor immunotherapy, the side effects associated with the intestinal flora, intestinal flora influence mechanism of the effect of tumor immunotherapy, eventually selected curative effect and prognosis prediction of intestinal flora markers, and developing new probiotics to improve the effect of tumor immunotherapy, help clinical cancer treatment. The study of tumor immunotherapy and intestinal flora can be applied to the study of intestinal flora with different cancer species and different immunotherapy strategies.